# Power and Sample Size Calculation for Non-Proportional Hazards and Beyond

## Documentation for package ‘lrstat’ version 0.2.4

- DESCRIPTION file.
- User guides, package vignettes and other documentation.
- Package NEWS.

## Help Pages

A B C E F G H K L M N P Q R S U

## -- A --

accrual | Number of enrolled subjects
adaptDesign | Adaptive design at an interim look

## -- B --

BOINTable | BOIN decision table

## -- C --

caltime | Calendar times for target number of events
ClopperPearsonCI | Clopper-Pearson confidence interval for one-sample proportion
covrmst | Covariance between restricted mean survival times

## -- E --

errorSpent | Error spending
exitprob | Stagewise exit probabilities

## -- F --

fadjpbon | Adjusted p-values for Bonferroni-based graphical approaches
fadjpdun | Adjusted p-values for Dunnett-based graphical approaches
fadjpsim | Adjusted p-values for Simes-based graphical approaches
fmodmix | Adjusted p-values for modified mixture gatekeeping procedures
fseqbon | Group sequential trials using Bonferroni-based graphical approaches
fstdmix | Adjusted p-values for standard mixture gatekeeping procedures
fstp2seq | Adjusted p-values for stepwise testing procedures for two sequences
ftrunc | Adjusted p-values for Holm, Hochberg, and Hommel procedures
fwgtmat | Weight matrix for all intersection hypotheses

## -- G --

getAccrualDurationFromN | Accrual duration to enroll target number of subjects
getADCI | Confidence interval after adaptation
getADRCI | Repeated confidence interval after adaptation
getBound | Efficacy boundaries for group sequential design
getCI | Confidence interval after trial termination
getCP | Conditional power allowing for varying parameter values
getDesign | Power and sample size for a generic group sequential design
getDesignAgreement | Power and sample size for Cohen's kappa
getDesignANOVA | Power and sample size for one-way ANOVA
getDesignANOVAContrast | Power and sample size for one-way ANOVA contrast
getDesignEquiv | Power and sample size for a generic group sequential equivalence design
getDesignFisherExact | Power and sample size for Fisher's exact test for two proportions
getDesignLogistic | Power and sample size for logistic regression
getDesignMeanDiff | Group sequential design for two-sample mean difference
getDesignMeanDiffCarryover | Power and sample size for direct treatment effects in crossover trials accounting for carryover effects
getDesignMeanDiffEquiv | Group sequential design for equivalence in two-sample mean difference
getDesignMeanDiffMMRM | Power and sample size for two-sample mean difference at the last time point from the MMRM model
getDesignMeanDiffXO | Group sequential design for mean difference in 2x2 crossover
getDesignMeanDiffXOEquiv | Group sequential design for equivalence in mean difference in 2x2 crossover
getDesignMeanRatio | Group sequential design for two-sample mean ratio
getDesignMeanRatioEquiv | Group sequential design for equivalence in two-sample mean ratio
getDesignMeanRatioXO | Group sequential design for mean ratio in 2x2 crossover
getDesignMeanRatioXOEquiv | Group sequential design for equivalence in mean ratio in 2x2 crossover
getDesignOddsRatio | Group sequential design for two-sample odds ratio
getDesignOddsRatioEquiv | Group sequential design for equivalence in two-sample odds ratio
getDesignOneMean | Group sequential design for one-sample mean
getDesignOneMultinom | Power and sample for one-sample multinomial response
getDesignOneProportion | Group sequential design for one-sample proportion
getDesignOneRateExact | Power and sample size for one-sample Poisson rate exact test
getDesignOneSlope | Group sequential design for one-sample slope
getDesignOrderedBinom | Power and sample size for Cochran-Armitage trend test for ordered multi-sample binomial response
getDesignPairedMeanDiff | Group sequential design for paired mean difference
getDesignPairedMeanDiffEquiv | Group sequential design for equivalence in paired mean difference
getDesignPairedMeanRatio | Group sequential design for paired mean ratio
getDesignPairedMeanRatioEquiv | Group sequential design for equivalence in paired mean ratio
getDesignPairedPropMcNemar | Group sequential design for McNemar's test for paired proportions
getDesignRepeatedANOVA | Power and sample size for repeated-measures ANOVA
getDesignRepeatedANOVAContrast | Power and sample size for one-way repeated measures ANOVA contrast
getDesignRiskDiff | Group sequential design for two-sample risk difference
getDesignRiskDiffEquiv | Group sequential design for equivalence in two-sample risk difference
getDesignRiskDiffExact | Power and sample size for exact unconditional test for risk difference
getDesignRiskDiffExactEquiv | Power and sample size for exact unconditional test for equivalence in risk difference
getDesignRiskRatio | Group sequential design for two-sample risk ratio
getDesignRiskRatioEquiv | Group sequential design for equivalence in two-sample risk ratio
getDesignRiskRatioExact | Power and sample size for exact unconditional test for risk ratio
getDesignRiskRatioExactEquiv | Power and sample size for exact unconditional test for equivalence in risk ratio
getDesignRiskRatioFM | Group sequential design for two-sample risk ratio based on the Farrington-Manning score test
getDesignSlopeDiff | Group sequential design for two-sample slope difference
getDesignSlopeDiffMMRM | Power and sample for two-sample slope difference from the MMRM model
getDesignTwoMultinom | Power and sample for difference in two-sample multinomial response
getDesignTwoOrdinal | Power and sample size for the Wilcoxon test for two-sample ordinal response
getDesignTwoWayANOVA | Power and sample size for two-way ANOVA
getDesignUnorderedBinom | Power and sample size for unordered multi-sample binomial response
getDesignUnorderedMultinom | Power and sample size for unordered multi-sample multinomial response
getDesignWilcoxon | Group sequential design for two-sample Wilcoxon test
getDurationFromNevents | Range of accrual duration for target number of events
getNeventsFromHazardRatio | Get the required number of events given hazard ratio
getRCI | Repeated confidence interval for group sequential design

## -- H --

hedgesg | Hedges' g effect size

## -- K --

kmpower | Power for difference in milestone survival probability
kmpower1s | Power for one-sample milestone survival probability
kmpowerequiv | Power for equivalence in milestone survival probability difference
kmsamplesize | Sample size for difference in milestone survival probability
kmsamplesize1s | Sample size for one-sample milestone survival probability
kmsamplesizeequiv | Sample size for equivalence in milestone survival probability difference
kmstat | Stratified difference in milestone survival probability

## -- L --

lrpower | Log-rank test power
lrpowerequiv | Power for equivalence in hazard ratio
lrsamplesize | Log-rank test sample size
lrsamplesizeequiv | Sample size for equivalence in hazard ratio
lrsim | Log-rank test simulation
lrsim2e | Log-rank test simulation for two endpoints
lrsim2e3a | Log-rank test simulation for two endpoints and three arms
lrsim3a | Log-rank test simulation for three arms
lrstat | Number of subjects having an event and log-rank statistics

## -- M --

mnOddsRatioCI | Miettinen-Nurminen score confidence interval for two-sample odds ratio
mnRateDiffCI | Miettinen-Nurminen score confidence interval for two-sample rate difference
mnRateRatioCI | Miettinen-Nurminen score confidence interval for two-sample rate ratio
mnRiskDiffCI | Miettinen-Nurminen score confidence interval for two-sample risk difference
mnRiskRatioCI | Miettinen-Nurminen score confidence interval for two-sample risk ratio
mTPI2Table | mTPI-2 decision table

## -- N --

nbpower | Power for negative binomial rate ratio
nbpower1s | Power for one-sample negative binomial rate
nbpowerequiv | Power for equivalence in negative binomial rate ratio
nbsamplesize | Sample size for negative binomial rate ratio
nbsamplesize1s | Sample size for one-sample negative binomial rate
nbsamplesizeequiv | Sample size for equivalence in negative binomial rate ratio
nbstat | Negative binomial rate ratio

## -- P --

ptpwexp | Distribution function of truncated piecewise exponential distribution

## -- Q --

qtpwexp | Quantile function of truncated piecewise exponential distribution

## -- R --

remlOddsRatio | REML estimates of individual proportions with specified odds ratio
remlRateDiff | REML estimates of individual rates with specified rate difference
remlRateRatio | REML estimates of individual rates with specified rate ratio
remlRiskDiff | REML estimates of individual proportions with specified risk difference
remlRiskRatio | REML estimates of individual proportions with specified risk ratio
repeatedPValue | Repeated p-values for group sequential design
rmpower | Power for difference in restricted mean survival time
rmpower1s | Power for one-sample restricted mean survival time
rmpowerequiv | Power for equivalence in restricted mean survival time difference
rmsamplesize | Sample size for difference in restricted mean survival time
rmsamplesize1s | Sample size for one-sample restricted mean survival time
rmsamplesizeequiv | Sample size for equivalence in restricted mean survival time difference
rmst | Restricted mean survival time
rmstat | Stratified difference in restricted mean survival time
rtpwexp | Random number generation function of truncated piecewise exponential distribution
runShinyApp | Run Shiny app

## -- S --

simon2stage | Simon's two-stage design
survQuantile | Brookmeyer-Crowley confidence interval for quantiles of right-censored time-to-event data

## -- U --

updateGraph | Update graph for graphical approaches